Dried blood spot (DBS) analysis has been known for more than five decades. It is an easy way of collecting, shipping and storing blood samples. In recent years the usage of dried blood spots (DBS) has gained increasing importance since this method shows strong advantages compared to the conventional collection and analysis of blood or plasma samples. These advantages include the need for remarkably lower blood volumes and easier shipping and storage, often at ambient temperatures. This leads to a simplification of the blood collection process and a significant reduction of the costs involved.